Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation
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Glycogen synthase kinase-3β may contribute to neuroprotective effects of Sargassum oligocystum against amyloid-beta in neuronal SH-SY5Y cells
Glycogen synthase kinase (GSK)-3β mediates amyloid-beta (Aβ) and oxidative stress-induced neurotoxicity in neurodegenerative disorders. Natural products with antioxidant activity, such as Sargassum (S.) oligocystum may modulate GSK-3β enzyme and protect against Aβ-induced neurotoxicity. Therefore, we aimed to assess the neuroprotective effects of a methanolic extract of S. oligocystum against A...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2008
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-007-0914-7